Results
| PMID | 20850729 |
| Gene Name | SOX2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 36 |
| Population details | 36 patients |
| Sex | Female |
| Associated genes | SOX-2, OCT-4, KLF-4, and NANOG |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2011 Jan;95(1):338-41. doi: 10.1016/j.fertnstert.2010.08.006. Epub Gotte, Martin| Wolf, Maria| Staebler, Annette| Buchweitz, Olaf| Kiesel, Ludwig| Schuring, Andreas N Department of Gynecology and Obstetrics, University of Munster, Medical Center, Munster, Germany. martingotte@uni-muenster.de Expression of the pluripotency factors SOX-2, OCT-4, KLF-4, and NANOG was analyzed by quantitative real-time polymerase chain reaction, immunohistochemistry, and immunofluorescence microscopy in the endometrium, myometrium, and endometriotic tissue of 36 patients. Aberrant expression of SOX-2 may indicate a stem cell origin of endometriosis, whereas the presence of all progenitor markers in endometrial tissue marks the endometrium as a potential source for induced pluripotent stem cell generation. Mesh Terms: Adult| Biomarkers/*metabolism| *Endometriosis/genetics/metabolism/pathology| Endometrium/pathology/*physiology| Female| Gene Expression/physiology| Homeodomain Proteins/genetics| Humans| Kruppel-Like Transcription Factors/genetics| Middle Aged| |
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